Blood Syndicate #31 (Oct. 1995):
by D. G. Chichester, Elim Mak, Rober Quijano
12 characters in this story:
Text on cover:
"Soul Breaker Strikes!
A subterranean threat made of science and magic attacks the Syndicate in their most vulnerable spot - Brickhouse and the Third Rail!"
Summary from now-defunct webpage at http://milestone.luthor.com/comics_detail.asp?ID=89&:
We are introduced to the Soul Breaker. We see Barton Aygrad (of Long Hot Summer fame) get hired by Brickhouse and Third Rail. Third Rail gets kidnapped by the Soul Breaker. The Syndicate goes hunting for Third Rail and finds that Soul Breaker has taken over his mind.